Metabolomic Profiling of Amino Acids and β-Cell Function Relative to Insulin Sensitivity in Youth
نویسندگان
چکیده
منابع مشابه
Measuring β-Cell Function Relative to Insulin Sensitivity in Youth
OBJECTIVE To compare β-cell function relative to insulin sensitivity, disposition index (DI), calculated from two clamps (2cDI, insulin sensitivity from the hyperinsulinemic-euglycemic clamp and first-phase insulin from the hyperglycemic clamp) with the DI calculated from the hyperglycemic clamp alone (hcDI). RESEARCH DESIGN AND METHODS Complete data from hyperglycemic and hyperinsulinemic-eu...
متن کاملPubertal changes of insulin sensitivity, acute insulin response, and β-cell function in overweight Latino youth.
OBJECTIVE To examine changes in insulin sensitivity (SI), compensatory acute insulin response (AIR), and β-cell function/disposition index (DI) across puberty in overweight Latino boys and girls. STUDY DESIGN Latino children (n = 253) were followed annually for up to 5 years. Longitudinal modeling was used to examine changes in SI, AIR, DI, and fasting and 2-hour glucose and insulin across Ta...
متن کامل25-Hydroxyvitamin D Concentrations and In Vivo Insulin Sensitivity and β-Cell Function Relative to Insulin Sensitivity in Black and White Youth
OBJECTIVE To examine the relationships between plasma 25-hydroxyvitamin D [25(OH)D] and in vivo insulin sensitivity and β-cell function relative to insulin sensitivity, disposition index (DI), in black and white youth. RESEARCH DESIGN AND METHODS Plasma 25(OH)D concentrations were analyzed in banked specimens in healthy youth aged 8 to 18 years who had existing data on hyperinsulinemic-euglyc...
متن کامل25-Hydroxyvitamin D concentrations and in vivo insulin sensitivity and β-cell function relative to insulin sensitivity in black and white youth. Diabetes Care 2012;35:627–633
D concentrations and in vivo insulin sensitivity and b-cell function relative to insulin sensitivity in black and white youth. In the print version of the article listed above, in the " Biochemical Measurements " section, the sentence " The intrassay and interassay coefficients of variation were 8 ng/mL and 10 ng/mL, respectively " should read as follows: " The intraassay and interassay coeffic...
متن کاملMeasuring b-Cell Function Relative to Insulin Sensitivity in Youth Does the hyperglycemic clamp suffice?
RESEARCH DESIGN AND METHODSdComplete data from hyperglycemic and hyperinsulinemic-euglycemic clamps were available for 330 youth, including 73 normal weight (NW), 168 obese with normal glucose tolerance (OB-NGT), 57 obese with impaired glucose tolerance (OB-IGT), and 32 obese with type 2 diabetes (OB-T2DM). The correlation between hcDI and 2cDI and Bland-Altman analysis of agreement between the...
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ژورنال
عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism
سال: 2012
ISSN: 0021-972X,1945-7197
DOI: 10.1210/jc.2012-2170